The integrative McDonald & Kreitman test

The iMKT page allows performing diverse MK-derived tests as a web-based service. The McDonald & Kreitman test is used to estimate the fraction of substitutions fixed by positive selection (α).

MKT analysis

Estimate the selective regimes in your set of coding sequences from polymorphism and divergence data or multi-FASTA files.

PopFly data analysis

Analyze the selective regimes of 13,753 protein-coding genes in 16 populations of D. melanogaster using PopFly data.

PopHuman data analysis

Analyze the selective regimes of 20,643 protein-coding genes in 26 human populations using data from PopHuman.

Help and tutorial

This page will guide you through iMKT site by following a step-by-step worked example.